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| Alejandro R. Roces | Profile |
1st Filipino to lead the campaign to change the Philippine Independence Day from July 4 to June 12 Philippine National Artist in Literature (2003) | 1960s |
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| Amado V. Hernandez | Profile |
1st Filipino National Artist in Literature
Philippine National Artist in Literature (1973) | 1973 |
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| Carlos Quirino | Profile |
1st Filipino National Artist in Historical Literature Philippine National Artist in Historical Literature (1997) | 1997 |
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| Carlos P. Romulo | Profile |
1st Filipino and 1st Asian Pulitzer Prize Winner in Journalism (English) Philippine National Artist in Literature (1982) | 1942 |
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| Fernando Amorsolo | Profile |
1st Filipino National Artist of the Republic of the Philippines Philippine National Artist in Painting (1972) | 1972 |
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| Fernando Poe, Jr. | Profile |
1st Filipino award-winning Action Star whose film Isusumbong Kita sa Tatay Ko became the 1st Philippine movie to exceed the P100 million mark in the box office Philippine National Artist for Cinema (2006) | 1999 |
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| Francisca Reyes Aquino | Profile |
1st Filipina National Artist for Dance Philippine National Artist in Dance (1973) | 1973 |
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| Gerardo De Leon | Profile |
1st Filipino National Artist for Cinema Philippine National Artist in Cinema (1982) | 1982 |
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| Honorata Dela Rama | Profile |
1st Filipina Film Actress of the 1st Tagalog movie Dalagang Bukid Philippine National Artist in Theater and Music (1987) | 1919 |
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| Jose Garcia Villa | Profile |
1st Filipino writer in English to be declared a National Artist Philippine National Artist in Literature (1973) | 1973 |
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| Jovita Fuentes | Profile |
1st Filipina National Artist in Music Philippine National Artist in Music (1976) | 1976 |
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| Juan F. Nakpil | Profile |
1st Filipino National Artist in Architecture
Philippine National Artist in Architecture (1973) | 1973 |
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| Lamberto V. Avellana | Profile |
1st Filipino National Artist in Theater and Film Philippine National Artist in Theater (1976) | 1976 |
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| Ramon Valera | Profile |
1st Filipino fashion designer to be declared a National Artist
Philippine National Artist in Fashion Design (2006)
| 2006 |
| Severino Montano | Profile |
1st Filipino to form a "legitimate theater" in the Philippines Philippine National Artist in Theater (2001) | 1960s |
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